GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer

被引：71

作者：

Hansen, Rikke Dalgaard ^{[1
,2
]}

Krath, Britta Naimi ^{[3
]}

Frederiksen, Kirsten ^{[1
]}

Tjonneland, Anne ^{[1
]}

Overvadd, Kim ^{[4
]}

Roswall, Nina ^{[1
]}

Loft, Steffen ^{[5
]}

Dragsted, Lars Ove ^{[3
]}

Vogel, Ulla ^{[2
,6
,7
]}

Raaschou-Nielsen, Ole ^{[1
]}

机构：

[1] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark

[2] Natl Res Ctr Working Environm, DK-2100 Copenhagen, Denmark

[3] Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1870 Frederiksberg C, Denmark

[4] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-9100 Aalborg, Denmark

[5] Univ Copenhagen, Inst Publ Hlth, Dept Occupat & Lifestyle Hlth, DK-1014 Copenhagen K, Denmark

[6] Tech Univ Denmark, Natl Food Inst, DK-2860 Soborg, Denmark

[7] Univ Roskilde, Inst Sci Syst & Models, DK-4000 Roskilde, Denmark

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2009年 / 664卷 / 1-2期

关键词：

Colorectal cancer; GPX1; OGG1; Gene-environment interaction; Enzyme activity; Oxidative stress; GLUTATHIONE-PEROXIDASE ACTIVITY; BREAST-CANCER; BLOOD SELENIUM; NO ASSOCIATION; COLON-CANCER; PRO198LEU POLYMORPHISM; SER326CYS POLYMORPHISM; LIPID-PEROXIDATION; PROSPECTIVE COHORT; OXIDATIVE STRESS;

D O I：

10.1016/j.mrfmmm.2009.01.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

GPX1 encoding the enzyme glutathione peroxiclase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures. We examined whether the polymorphisms GPX1 Pro(198)Leu and OGG1 Ser(326)CyS or low erythrocyte GPX enzyme activity in pre-diagnostic blood samples are associated with colorectal cancer risk, and assessed possible interactions between the polymorphisms or enzyme activity and various lifestyle factors in relation to colorectal cancer risk. Additionally, we studied whether the GPX1 Pro(198)Leu polymorphism and several lifestyle factors predict GPX activity in erythrocytes. The present study was nested within the prospective "Diet, Cancer and Health" study of 57,053 Danes including 375 colorectal cancer cases and a comparison group of 779 individuals matched on gender. Biomaterial was sampled and information on lifestyle factors was obtained from questionnaires filled in at enrolment in 1993-1997. GPX1 Pro(198)Leu, hOGG1 Ser(326)Cys and erythrocyte GPX enzyme activity were not associated with risk of colorectal cancer. We observed a higher risk associated with alcohol consumption and smoking among homozygous GPX1 (198)Leu carriers, with incidence rate ratios for colorectal cancer of 1.45 (95% CI: 1.17-1.81, P = 0.02) per 10 g alcohol intake per day and 2.56 (95% CI: 0.99-6.61, P = 0.02) among ever smokers compared with never smokers at enrolment. Erythrocyte GPX activity was influenced by the GPX1 Pro(198)Leu genotype, gender, smoking intensity. and intake of fruits and vegetables. Our results indicate that lifestyle-related oxidative stress may be a risk factor for colorectal cancer among subjects with a lowered defence. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：13 / 19

页数：7

共 49 条

[31]

2-2

[32]

PAGLIA DE, 1967, J LAB CLIN MED, V70, P158

[33] GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer [J].

Raaschou-Nielsen, Ole ;

Sorensen, Mette ;

Hansen, Rikke D. ;

Frederiksen, Kirsten ;

Tjonneland, Anne ;

Overvad, Kim ;

Vogel, Ulla .

CANCER LETTERS, 2007, 247 (02) :293-300

[34] Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae [J].

Radicella, JP ;

Dherin, C ;

Desmaze, C ;

Fox, MS ;

Boiteux, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :8010-8015

[35]

Ratnasinghe D, 2000, CANCER RES, V60, P6381

[36] Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study [J].

Ravn-Haren, G ;

Olsen, A ;

Tjonneland, A ;

Dragsted, LO ;

Nexo, BA ;

Wallin, H ;

Overvad, K ;

Raaschou-Nielsen, O ;

Vogel, U .

CARCINOGENESIS, 2006, 27 (04) :820-825

[37] BLOOD SELENIUM AND GLUTATHIONE-PEROXIDASE ACTIVITY IN NORMAL SUBJECTS AND IN SURGICAL PATIENTS WITH AND WITHOUT CANCER IN NEW-ZEALAND [J].

ROBINSON, MF ;

GODFREY, PJ ;

THOMSON, CD ;

REA, HM ;

VANRIJ, AM .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1979, 32 (07) :1477-1485

[38] Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase [J].

RoldanArjona, T ;

Wei, YF ;

Carter, KC ;

Klungland, A ;

Anselmino, C ;

Wang, RP ;

Augustus, M ;

Lindahl, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :8016-8020

[39] EFFECT OF SELENIUM STATUS ON MESSENGER-RNA LEVELS FOR GLUTATHIONE-PEROXIDASE IN RAT-LIVER [J].

SAEDI, MS ;

SMITH, CG ;

FRAMPTON, J ;

CHAMBERS, I ;

HARRISON, PR ;

SUNDE, RA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 153 (02) :855-861

[40] SMOKE COMPOSITION - EXTENSIVE INVESTIGATION OF WATER-SOLUBLE PORTION OF CIGARETTE-SMOKE [J].

SCHUMACHER, JN ;

GREEN, CR ;

BEST, FW ;

NEWELL, MP .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1977, 25 (02) :310-320

← 1 2 3 4 5 →