Metabolomic approaches to phenotype characterization and applications to complex diseases

被引：67

作者：

Oresic, Matej

Vidal-Puig, Antonio

Hanninen, Virve

机构：

[1] VTT Tech Res Ctr Finland, FIN-02044 Espoo, Finland

[2] Zora Biosci Ltd, FIN-02044 Espoo, Finland

[3] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem & Metab Med, Cambridge CB2 2QR, England

[4] Orion Pharma, Clin Res & Dev, FIN-02101 Espoo, Finland

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2006年 / 6卷 / 04期

基金：

英国医学研究理事会;

关键词：

biomarker; critical path research; metabolomics; pharmacology; quantitative disease model; systems biology; toxicology; translational path research;

D O I：

10.1586/14737159.6.4.575

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Metabolites are the key regulators of systems homeostasis. As such, concentration changes of specific groups of metabolites may reflect systemic responses to environmental, therapeutic or genetic interventions. Thus, the study of metabolites is a powerful tool for the characterization of complex phenotypes as well as for the development of biomarkers for specific physiological responses. Therefore, metabolomics is a valuable platform for studies of complex diseases and the development of new therapies, both in nonclinical disease model characterization and clinical settings.

引用

收藏

页码：575 / 585

页数：11

相关论文

共 67 条

[41] Summary recommendations for standardization and reporting of metabolic analyses [J].

Lindon, JC ;

Nicholson, JK ;

Holmes, E ;

Keun, HC ;

Craig, A ;

Pearce, JTM ;

Bruce, SJ ;

Hardy, N ;

Sansone, SA ;

Antti, H ;

Jonsson, P ;

Daykin, C ;

Navarange, M ;

Beger, RD ;

Verheij, ER ;

Amberg, A ;

Baunsgaard, D ;

Cantor, GH ;

Lehman-McKeeman, L ;

Earll, M ;

Wold, S ;

Johansson, E ;

Haselden, JN ;

Kramer, K ;

Thomas, C ;

Lindberg, J ;

Schuppe-Koistinen, I ;

Wilson, ID ;

Reily, MD ;

Robertson, DG ;

Senn, H ;

Krotzky, A ;

Kochhar, S ;

Powell, J ;

van der Ouderaa, F ;

Plumb, R ;

Schaefer, H ;

Spraul, M .

NATURE BIOTECHNOLOGY, 2005, 23 (07) :833-838

[42] Metabonomics and its role in drug development and disease diagnosis [J].

Lindon, JC ;

Holmes, E ;

Nicholson, JK .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2004, 4 (02) :189-199

[43] Direct qualitative analysis of triacylglycerols by electrospray mass spectrometry using a linear ion trap [J].

McAnoy, AM ;

Wu, CC ;

Murphy, RC .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2005, 16 (09) :1498-1509

[44] The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-γ2 isoform [J].

Medina-Gomez, G ;

Virtue, S ;

Lelliott, C ;

Boiani, R ;

Campbell, M ;

Christodoulides, C ;

Perrin, C ;

Jimenez-Linan, M ;

Blount, M ;

Dixon, J ;

Zahn, D ;

Thresher, RR ;

Aparicio, S ;

Carlton, M ;

Colledge, WH ;

Kettunen, MI ;

Seppänen-Laakso, T ;

Sethi, JK ;

O'Rahilly, S ;

Brindle, K ;

Cinti, S ;

Oresic, M ;

Burcelin, R ;

Vidal-Puig, A .

DIABETES, 2005, 54 (06) :1706-1716

[45] Metabonomics: a platform for studying drug toxicity and gene function [J].

Nicholson, JK ;

Connelly, J ;

Lindon, JC ;

Holmes, E .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (02) :153-161

[46] Understanding 'global' systems biology: Metabonomics and the continuum of metabolism [J].

Nicholson, JK ;

Wilson, ID .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (08) :668-676

[47] Gut microorganisms, mammalian metabolism and personalized health care [J].

Nicholson, JK ;

Holmes, E ;

Wilson, ID .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (05) :431-438

[48] Connecting genes to metabolites by a systems biology approach [J].

Oksman-Caldentey, KM ;

Inzé, D ;

Oresic, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (27) :9949-9950

[49]

Oresic Matej, 2004, Appl Bioinformatics, V3, P205

[50] QUANTITATIVE ANALYSIS OF URINE VAPOR AND BREATH BY GAS-LIQUID PARTITION CHROMATOGRAPHY [J].

PAULING, L ;

ROBINSON, AB ;

TERANISH.R ;

CARY, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (10) :2374-&

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