The management of colorectal liver metastases: Expanding the role of hepatic resection in the age of multimodal therapy

被引：23

作者：

Chiappa, A. ^{[1
]}

Makuuchi, M. ^{[2
]}

Lygidakis, N. J. ^{[3
]}

Zbar, A. P. ^{[4
]}

Chong, G. ^{[5
]}

Bertani, E. ^{[1
]}

Sitzler, P. J. ^{[7
]}

Biffi, R. ^{[1
]}

Pace, U. ^{[1
]}

Bianchi, P. P. ^{[1
]}

Contino, G. ^{[1
]}

Misitano, P. ^{[1
]}

Orsi, F. ^{[6
]}

Travaini, L. ^{[8
]}

Trifiro, G. ^{[8
]}

Zampino, M. G. ^{[9
]}

Fazio, N. ^{[9
]}

Goldhirsch, A. ^{[9
]}

Andreoni, B. ^{[1
]}

机构：

[1] Univ Milan, Dept Gen Surg Laparoscop Surg, European Inst Oncol, Milan, Italy

[2] Univ Tokyo, Tokyo Univ Hosp, Grad Sch Med, Dept Surg, Tokyo, Japan

[3] Med Ctr Psychiko, Dept Surg Oncol, Athens, Greece

[4] Univ Tasmania, Sch Human Life Sci, Hobart, Tas 7001, Australia

[5] Camberra Hosp, Canberra, ACT, Australia

[6] European Inst Oncol, Dept Radiol, I-20141 Milan, Italy

[7] Monash Med Ctr, Melbourne, Vic, Australia

[8] European Inst Oncol, Dept Med, Div Nucl Med, I-20141 Milan, Italy

[9] European Inst Oncol, Dept Med, Div Med Oncol, I-20141 Milan, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2009年 / 72卷 / 01期

关键词：

Colorectal cancer; Hepatic metastases; Surgery; Neoadjuvant therapy; Survival; Disease-free survival; ENDOTHELIAL GROWTH-FACTOR; PERCUTANEOUS RADIOFREQUENCY ABLATION; POSITRON-EMISSION-TOMOGRAPHY; PORTAL-VEIN EMBOLIZATION; NEOADJUVANT CHEMOTHERAPY; SURGICAL RESECTION; MAJOR HEPATECTOMY; TUMOR RESPONSE; PREOPERATIVE CHEMOTHERAPY; VASCULAR EXCLUSION;

D O I：

10.1016/j.critrevonc.2008.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) caused nearly 204,000 deaths in Europe in 2004. Despite recent advances in the treatment of advanced disease, which include the incorporation of two new cytotoxic agents irinotecan and oxaliplatin into first-line regimens, the concept of planned sequential therapy involving three active agents during the course of a patient's treatment and the integrated use of targeted monoclonal antibodies, the 5-year survival rates for patients with advanced CRC remain unacceptably low. For patients with colorectal liver metastases, liver resection offers the only potential for cure. This review, based on the outcomes of a meeting of European experts (surgeons and medical oncologists), considers the current treatment strategies available to patients with CRC liver metastases, the criteria for the selection of those patients most likely to benefit and suggests where future progress may occur. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：65 / 75

页数：11

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