FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

被引：234

作者：

Brinkmann, V

Lynch, KR

机构：

[1] Novartis Pharma AG, Transplantat Res, CH-4002 Basel, Switzerland

[2] Univ Virginia Hlth Syst, Dept Pharmacol, Charlottesville, VA 22908 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(02)00374-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The novel immunomodulator FTY720 is remarkably effective in models of transplantation and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：569 / 575

页数：7

共 45 条

[41] Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors [J].