Saccharomyces cerevisiae as a vaccine against coccidioidomycosis

被引：43

作者：

Capilla, Javier ^{[2
,3
]}

Clemons, Karl V. ^{[1
,2
,3
]}

Liu, Min ^{[2
,3
]}

Levine, Hillel B. ^{[2
]}

Stevens, David A. ^{[2
,3
]}

机构：

[1] Santa Clara Valley Med Ctr, Div Infect Dis, San Jose, CA 95128 USA

[2] Calif Inst Med Res, San Jose, CA 95128 USA

[3] Stanford Univ, Stanford, CA 94305 USA

来源：

VACCINE | 2009年 / 27卷 / 27期

关键词：

Coccidioides; Vaccines; Coccidioidal vaccine; PROLINE-RICH ANTIGEN; BETA-GLUCAN; IMMITIS; MICE; PROTECTION; PROTEIN; INFECTION; POSADASII; CONJUGATE; EFFICACY;

D O I：

10.1016/j.vaccine.2009.03.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Disseminated coccidioidomycosis is a life-threatening infection. In these studies, we examined protection against systemic murine coccidioidomycosis by vaccination with heat-killed Saccharomyces cerevisiae (HKY). CD-1 mice received HKY subcutaneously or by oral gavage with or without adjuvants once weekly beginning 3 or 4 weeks prior to infection; oral live Saccharomyces was also studied. All HKY sc regimens were equivalent, prolonging survival (P <= 0.005) and reducing fungal burden versus controls. Oral live Saccharomyces, but not HKY, prolonged survival (P=0.03), but did not reduce fungal burden. Survival of mice given HKY was equivalent to vaccination with formalin-killed spherules, but inferior in reduction of fungal burden. HKY was superior to a successful recombinant vaccine, PRA plus adjuvant. This novel heterologous protection afforded by HKY vaccination offers a new approach to a vaccine against coccidioidomycosis. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3662 / 3668

页数：7

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