Evidence for autoregulation of cystathionine γ-synthase mRNA stability in Arabidopsis

被引：139

作者：

Chiba, Y

Ishikawa, M

Kijima, F

Tyson, RH

Kim, J

Yamamoto, A

Nambara, E

Leustek, T

Wallsgrove, RM

Naito, S ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Sapporo, Hokkaido 0608589, Japan

[2] AFRC, Inst Arable Crops Res, Dept Biochem & Physiol, Harpenden AL5 2JQ, Herts, England

[3] Rutgers State Univ, Biotechnol Ctr Agr & Environm, New Brunswick, NJ 08901 USA

来源：

SCIENCE | 1999年 / 286卷 / 5443期

关键词：

D O I：

10.1126/science.286.5443.1371

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Control of messenger RNA (mRNA) stability serves as an important mechanism, for regulating gene expression. Analysis of Arabidopsis mutants that overaccumulate soluble methionine (Met) revealed that the gene for cystathionine gamma-synthase (CCS), the key enzyme in Met biosynthesis, is regulated at the Level of mRNA stability, Transfection experiments with wild-type and mutant forms of the CCS gene suggest that an amino acid sequence encoded by the first exon of CCS acts in cis to destabilize its own mRNA in a process that is activated by Met or one of its metabolites.

引用

页码：1371 / 1374

页数：4

共 31 条

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