Determination of fluoxetine and norfluoxetine in human plasma by ion-interaction RP-HPLC

被引：8

作者：

Gennaro, MC ^{[1
]}

Abrigo, C ^{[1
]}

Angelino, S ^{[1
]}

Albert, U ^{[1
]}

Bogetto, F ^{[1
]}

Maina, G ^{[1
]}

Prolo, P ^{[1
]}

Ravizza, L ^{[1
]}

机构：

[1] UNIV TURIN,CATTEDRA PSICHIAT 1 & 3,I-10126 TURIN,ITALY

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1997年 / 20卷 / 18期

关键词：

D O I：

10.1080/10826079708006577

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The paper reports a sensitive Ion-Interaction Reverse Phase HPLC-UV method for the separation and determination of fluoxetine ((+/-)N-methyl-(4-(trifluoromethyl)phenoxy) benzene-propanamine) in human plasma. An ODS silica-based column is used as the stationary phase and the mobile phase consists of 5.00 mM octylamine in water/acetonitrile (60/40 v/v), at pH = 6.4, with UV detection at 230 nm. The method is selective towards potentially interferent drugs, such as paroxetine, amylsulpride, mianserin, imipramine, amitryptiline, maprotiline, haloperidol, flunitrazepam and diazepam. The proposed method was successfully applied to the determination of fluoxetine and norfluoxetine in plasma of some patients being treated for obsessive-compulsive disorders.

引用

页码：3017 / 3028

页数：12

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