Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines

被引：112

作者：

Belyakov, IM ^{[1
]}

Berzofsky, JA ^{[1
]}

机构：

[1] NCI, Vaccine Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2004年 / 20卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(04)00053-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal tissues are the primary site of natural HIV transmission and a major reservoir for HIV replication. Targeting immune responses to the mucosal entry site before viral dissemination could protect and also clear viral reservoirs. Recent understanding of mucosal HIV transmission and of chemokines and integrins in mucosal trafficking can aid design of new strategies to enhance AIDS vaccine efficacy.

引用

页码：247 / 253

页数：7

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