Enantioselective synthesis of the [6,6] spiroketal core of reveromycin A

被引：19

作者：

Drouet, KE ^{[1
]}

Ling, TT ^{[1
]}

Tran, HV ^{[1
]}

Theodorakis, EA ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 02期

关键词：

D O I：

10.1021/ol991290v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reveromycin A (1) belongs to a family of microbial polyketides with unusual structural features and biological activities. The structure of 1 is composed of a [6,6] spiroketal core decorated with highly unsaturated side chains, As a prelude to the synthesis of 1, we present herein a short, efficient, and enantioselective synthesis of the C9-C21 fragment 5 (spiroketal core) of reveromycin A.

引用

页码：207 / 210

页数：4

共 35 条

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