Focal adhesions: What's new inside

被引：123

作者：

Lo, Su Hao

机构：

[1] Univ Calif Davis, Dept Orthopaed Surg, Ctr Tissue Regenerat & Repair, Sacramento, CA 95817 USA

[2] Univ Calif Davis, Ctr Canc, Sacramento, CA 95817 USA

来源：

DEVELOPMENTAL BIOLOGY | 2006年 / 294卷 / 02期

关键词：

focal adhesion; cartilage; knockout mouse; mutant fly;

D O I：

10.1016/j.ydbio.2006.03.029

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cytoplasmic side of focal adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene expression. These complexes are heterogeneous and dynamic structures that are apparent targets of regulatory signals that control the function of focal adhesions. Recent studies using genetic approaches in invertebrate and vertebrate systems have begun to reveal the structure and function of these complexes in vivo. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：280 / 291

页数：12

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