Hollow mesoporous silica nanoparticles as delivery vehicle of foot-and-mouth disease virus-like particles induce persistent immune responses in guinea pigs

被引：23

作者：

Bai, Manyuan ^{[1
,2
]}

Dong, Hu ^{[1
,2
]}

Su, Xin ^{[1
,2
,3
]}

Jin, Ye ^{[1
,2
]}

Sun, Shiqi ^{[1
,2
]}

Zhang, Yingpeng ^{[3
]}

Yang, Yunshang ^{[3
]}

Guo, Huichen ^{[1
,2
]}

机构：

[1] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Minist Agr, Xujiaping 1, Lanzhou 730046, Gansu, Peoples R China

[2] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Anim Virol, Minist Agr, Xujiaping 1, Lanzhou 730046, Gansu, Peoples R China

[3] Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou, Gansu, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2019年 / 91卷 / 06期

关键词：

foot-and-mouth disease; guinea pigs; hollow mesoporous silicananoparticles; immunization; virus-like particles; ESCHERICHIA-COLI; VACCINE; ANTIGEN; ADJUVANT; CARRIERS; SYSTEM;

D O I：

10.1002/jmv.25417

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Foot-and-mouth disease (FMD) is an acute and febrile infectious disease, which can cause great economic losses. Virus-like particles (VLPs) as an advantageous antigen can induce significant specific immune response. To improve immunity of VLPs, especially, make it induce persistent immune response, the hollow mesoporous silica nanoparticles (HMSNs) as a potential nano-adjuvant were synthesized and loaded the FMD virus (FMDV) VLPs. They were injected into guinea pigs and the specific immune response was detected. The results confirmed that HMSNs/VLPs can induce persistent humoral immunity with high-level antibody titer for more than three months. HMSNs also improve the T-lymphocyte proliferation and IFN-gamma induced by FMDV VLPs, and provides the ideal protection against FMDV challenge. These consequences indicated that HMSNs were good protein delivery vehicle and potential nano-adjuvant of vaccines.

引用

页码：941 / 948

页数：8

共 35 条

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