Virus-like particles-flexible platforms for vaccine development

被引：243

作者：

Chackerian, Bryce ^{[1
]}

机构：

[1] Univ New Mexico, Sch Med, Ctr Infect Dis & Immun,Canc Res & Treatment Ctr, Dept Mol Genet & Microbiol,Canc Biol Program, Albuquerque, NM 87131 USA

来源：

EXPERT REVIEW OF VACCINES | 2007年 / 6卷 / 03期

关键词：

antibody induction; cytotoxic T lyinphocyte; self-antigen; virus-fike particle;

D O I：

10.1586/14760584.6.3.381

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus-like particles (VLPs) consist of viral structural proteins that, when overexpressed, spontaneously self-assemble into particles that are antigenically indistinguishable from infectious virus or subviral particles. VLPs can be considered as dense, repetitive arrays of one or more protein subunits with properties that are highly advantageous for use as stand-alone vaccines or as vaccine platforms. This review discusses the development of VLP-based platform technologies for vaccines against pathogens, as well as nontraditional targets such as self-antigens involved in chronic diseases.

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页码：381 / 390

页数：10

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