Reactive oxygen species signaling in vascular smooth muscle cells

被引：282

作者：

Clempus, Roza E. ^{[1
]}

Griendling, Kathy K. ^{[1
]}

机构：

[1] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 71卷 / 02期

关键词：

oxygen radicals; NADPH oxidase; signal transduction; smooth muscle;

D O I：

10.1016/j.cardiores.2006.02.033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：216 / 225

页数：10

共 104 条

[1] Fyn and JAK2 mediate Ras activation by reactive oxygen species [J].

Abe, J ;

Berk, BC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :21003-21010

[2] S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells [J].

Adachi, T ;

Pimentel, DR ;

Heibeck, T ;

Hou, XY ;

Lee, YJ ;

Jiang, BB ;

Ido, Y ;

Cohen, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (28) :29857-29862

[3] Direct interaction of the novel nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase [J].

Ambasta, RK ;

Kumar, P ;

Griendling, KK ;

Schmidt, HHHW ;

Busse, R ;

Brandes, RP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (44) :45935-45941

[4]

Ambasta RK, 2004, CIRCULATION, V110, P157

[5] Loss of caveolin-1 polarity impedes endothelial cell polarization and directional movement [J].

Beardsley, A ;

Fang, K ;

Mertz, H ;

Castranova, V ;

Friend, S ;

Liu, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (05) :3541-3547

[6] Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21waf1/cip1 [J].

Bhanoori, M ;

Yellaturu, CR ;

Ghosh, SK ;

Hassid, A ;

Jennings, LK ;

Rao, GN .

ONCOGENE, 2003, 22 (01) :117-130

[7] Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species [J].

Bleeke, T ;

Zhang, H ;

Madamanchi, N ;

Patterson, C ;

Faber, JE .

CIRCULATION RESEARCH, 2004, 94 (01) :37-45

[8]

BONVENTRE JV, 1992, J AM SOC NEPHROL, V3, P128

[9] Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced. by growth factors [J].

Boureux, A ;

Furstoss, O ;

Simon, V ;

Roche, S .

JOURNAL OF CELL SCIENCE, 2005, 118 (16) :3717-3726

[10] The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression [J].

Brandes, RP ;

Miller, FJ ;

Beer, S ;

Haendeler, J ;

Hoffmann, J ;

Ha, T ;

Holland, SM ;

Görlach, A ;

Busse, R .

FREE RADICAL BIOLOGY AND MEDICINE, 2002, 32 (11) :1116-1122

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