The complement system in B cell regulation

被引：128

作者：

Carroll, MC

机构：

[1] Harvard Univ, Sch Med, CBR Inst Biomed Res Inc, Dept Pediat, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02115 USA

来源：

MOLECULAR IMMUNOLOGY | 2004年 / 41卷 / 2-3期

关键词：

humoral immunity; complement receptors; innate immunity; germinal centers; follicular dendritic cells;

D O I：

10.1016/j.molimm.2004.03.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Early studies of animals bearing natural deficiencies in complement C3 and C4 and mice transiently deficient in C3 suggested that the complement system played a role in humoral immunity. Identification and characterization of the complement receptors CD21 and CD35 and their expression on B lymphocytes provided evidence for a direct role for complement in "linkage of innate and adaptive immunity". More recent studies of mice bearing targeted deficiencies in complement proteins C3, C4 or the receptors CD21/CD35 has confirmed the importance of complement in B cell responses in vivo and extended our understanding to distinct stages in B cell differentiation in which complement participates in Immoral immunity. In this review, a role for complement is described in five distinct stages of B cell differentiation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：141 / 146

页数：6

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