Solvent-free solid acid-catalyzed electrophilic annelations:: A new green approach for the synthesis of substituted five-membered N-heterocycles

被引：104

作者：

Abid, Mohammed

Spaeth, Andrew

Torok, Bela

机构：

[1] Univ Massachusetts, Boston, MA 02125 USA

[2] Michigan Technol Univ, Houghton, MI 49931 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 15期

关键词：

carbazoles; indoles; K-10; montmorillonite; microwave heating; pyrroles; solid acids;

D O I：

10.1002/adsc.200606200

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyr-roles and indoles have been completed within minutes and provided excellent (75-98%) yields with practically 100% selectivity.

引用

收藏

页码：2191 / 2196

页数：6

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