Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest

被引：28

作者：

Cao, SG

Guza, RC

Miller, JS

Andriantsiferana, R

Rasamison, VE

Kingston, DGI

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Missouri Bot Garden, St Louis, MO 63166 USA

[3] Ctr Natl Applicat & Rech Pharmaceut, Antananarivo 101, Madagascar

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 06期

关键词：

D O I：

10.1021/np040058h

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridocarpusic acids A-E (1-5); three known triterpenoids, moronic acid (6), ursolic acid, and oleanolic acid; and two known flavonoids, 4',5-dihydroxy-7-methoxyflavone and 4',5-dihydroxy-3',7-dimethoxyflavone. The structures of the new compounds 1-5 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 3 showed significant cytotoxic activity in the A2780 assay, with an IC50 value of 0.7 mug/mL.

引用

页码：986 / 989

页数：4

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