Chromatin-level regulation of biosynthetic gene clusters

被引：285

作者：

Bok, Jin Woo ^{[2
,3
]}

Chiang, Yi-Ming ^{[1
,4
]}

Szewczyk, Edyta ^{[5
]}

Reyes-Domingez, Yazmid ^{[6
]}

Davidson, Ashley D. ^{[5
]}

Sanchez, James F. ^{[1
]}

Lo, Hsien-Chun ^{[1
]}

Watanabe, Kenji ^{[1
]}

Strauss, Joseph ^{[6
]}

Oakley, Berl R. ^{[5
]}

Wang, Clay C. C. ^{[1
,7
]}

Keller, Nancy P. ^{[2
,3
,8
]}

机构：

[1] Univ So Calif, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA 90089 USA

[2] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Plant Pathol, Madison, WI 53706 USA

[4] Chia Nan Univ Pharm & Sci, Grad Inst Pharmaceut Sci, Tainan, Taiwan

[5] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[6] Univ Vienna, Fungal Genom Unit, Austrian Res Ctr & BOKU, Vienna, Austria

[7] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA

[8] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 07期

基金：

奥地利科学基金会; 美国国家科学基金会; 美国国家卫生研究院;

关键词：

HISTONE H3; SECONDARY METABOLISM; CHEMICAL DIVERSITY; ASPERGILLUS; SEQUENCE; METHYLATION; COMPASS;

D O I：

10.1038/nchembio.177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.

引用

页码：462 / 464

页数：3

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