学术探索
学术期刊
新闻热点
数据分析
智能评审

A hundred years of Alzheimer's disease research

被引：400
作者：
Hardy, John
机构：
[1] NIA, Neurogenet Lab, Bethesda, MD 20892 USA
[2] UCL, Inst Neurol, Reta Lila Weston Inst, London WC2, England
来源：
NEURON | 2006年 / 52卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.neuron.2006.09.016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
On the 100(th) anniversary of Alzheimer's lecture describing the clinicopathological entity which bears his eponym, this article reviews the major areas of progress in our understanding of the disease and outlines the many gaps still remaining. The progress toward effective mechanistic therapy is reviewed.
引用
收藏
页码：3 / 13
页数：11
相关论文
共 165 条
  • [1] CHANGES IN THE BRAIN CATECHOLAMINES IN PATIENTS WITH DEMENTIA OF ALZHEIMER TYPE
    ADOLFSSON, R
    GOTTFRIES, CG
    ROOS, BE
    WINBLAD, B
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1979, 135 (SEP) : 216 - 223
  • [2] Alzheimer A., 1907, ALLG Z PSYCHIAT, V64, P146, DOI DOI 10.1002/CA.980080612
  • [3] Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase
    Asai, M
    Hattori, C
    Szabó, B
    Sasagawa, N
    Maruyama, K
    Tanuma, S
    Ishiura, S
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (01) : 231 - 235
  • [4] Atwood CS, 2003, SCIENCE, V299, P1014
  • [5] Amyloid-β:: A vascular sealant that protects against hemorrhage?
    Atwood, CS
    Bishop, GM
    Perry, G
    Smith, MA
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (03) : 356 - 356
  • [6] PHYSOSTIGMINE AND RECENT MEMORY - EFFECTS IN YOUNG AND AGED NONHUMAN-PRIMATES
    BARTUS, RT
    [J]. SCIENCE, 1979, 206 (4422) : 1087 - 1089
  • [7] THE HISTORY OF ALZHEIMERS-DISEASE - 3 DEBATES
    BEACH, TG
    [J]. JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES, 1987, 42 (03) : 327 - 349
  • [8] Alzheimer's disease: one disorder, too many genes?
    Bertram, L
    Tanzi, RE
    [J]. HUMAN MOLECULAR GENETICS, 2004, 13 : R135 - R141
  • [9] Bielschowsky M., 1902, NEW CENTRALBL, V21, P579
  • [10] Bird T D, 1989, Prog Clin Biol Res, V317, P229
12345678910