Computed tomography of x-ray index of refraction using the diffraction enhanced imaging method

被引:239
作者
Dilmanian, FA [1 ]
Zhong, Z
Ren, B
Wu, XY
Chapman, LD
Orion, I
Thomlinson, WC
机构
[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA
[2] Brookhaven Natl Lab, Natl Synchrotron Light Source, Upton, NY 11973 USA
[3] IIT, CSRRI, Chicago, IL 60616 USA
关键词
D O I
10.1088/0031-9155/45/4/309
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Diffraction enhanced imaging (DEI) is a new, synchrotron-based, x-ray radiography method that uses monochromatic, fan-shaped beams, with an analyser crystal positioned between the subject and the detector. The analyser allows the detection of only those x-rays transmitted by the subject that fall into the acceptance angle (central part of the rocking curve) of the monochromator/analyser system. As shown by Chapman et al, in addition to the x-ray attenuation, the method provides information on the out-of-plane angular deviation of x-rays. New images result in which the image contrast depends on the x-ray index of refraction and on the yield of small-angle scattering, respectively. We implemented DEI in the tomography mode at the National Synchrotron Light Source using 22 keV x-rays, and imaged a cylindrical acrylic phantom that included oil-filled, slanted channels. The resulting 'refraction CT image' shows the pure image of the out-of-plane gradient of the x-ray index of refraction. No image artefacts were present, indicating that the CT projection data were a consistent set. The 'refraction CT image' signal is linear with the gradient of the refractive index, and its value is equal to that expected. The method, at the energy used or higher, has the potential for use in clinical radiography and in industry.
引用
收藏
页码:933 / 946
页数:14
相关论文
共 21 条
[1]   Low-dose phase contrast x-ray medical imaging [J].
Arfelli, F ;
Assante, M ;
Bonvicini, V ;
Bravin, A ;
Cantatore, G ;
Castelli, E ;
Dalla Palma, L ;
Di Michiel, M ;
Longo, R ;
Olivo, A ;
Pani, S ;
Pontoni, D ;
Poropat, P ;
Prest, M ;
Rashevsky, A ;
Tromba, G ;
Vacchi, A ;
Vallazza, E ;
Zanconati, F .
PHYSICS IN MEDICINE AND BIOLOGY, 1998, 43 (10) :2845-2852
[2]   DYNAMICAL DIFFRACTION OF X RAYS BY PERFECT CRYSTALS [J].
BATTERMAN, BW ;
COLE, H .
REVIEWS OF MODERN PHYSICS, 1964, 36 (03) :681-&
[3]   Diffraction enhanced x-ray imaging [J].
Chapman, D ;
Thomlinson, W ;
Johnston, RE ;
Washburn, D ;
Pisano, E ;
Gmur, N ;
Zhong, Z ;
Menk, R ;
Arfelli, F ;
Sayers, D .
PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (11) :2015-2025
[4]  
Chapman D, 1998, BREAST IMAGING, P197, DOI 10.3233/BD-1998-103-419
[5]  
CHAPMAN D, 1995, REV SCI INSTRUM S, V67
[6]   PHASE-CONTRAST IMAGING OF WEAKLY ABSORBING MATERIALS USING HARD X-RAYS [J].
DAVIS, TJ ;
GAO, D ;
GUREYEV, TE ;
STEVENSON, AW ;
WILKINS, SW .
NATURE, 1995, 373 (6515) :595-598
[7]   COMPUTED-TOMOGRAPHY WITH MONOCHROMATIC X-RAYS FROM THE NATIONAL-SYNCHROTRON-LIGHT-SOURCE [J].
DILMANIAN, FA ;
GARRETT, RF ;
THOMLINSON, WC ;
BERMAN, LE ;
CHAPMAN, LD ;
HASTINGS, JB ;
LUKE, PN ;
OVERSLUIZEN, T ;
SIDDONS, DP ;
SLATKIN, DN ;
STOJANOFF, V ;
THOMPSON, AC ;
VOLKOW, ND ;
ZEMAN, HD .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1991, 56-7 :1208-1213
[8]   Single- and dual-energy CT with monochromatic synchrotron x-rays [J].
Dilmanian, FA ;
Wu, XY ;
Parsons, EC ;
Ren, B ;
Kress, J ;
Button, TM ;
Chapman, LD ;
Coderre, JA ;
Giron, F ;
Greenberg, D ;
Krus, DJ ;
Liang, Z ;
Marcovici, S ;
Petersen, MJ ;
Roque, CT ;
Shleifer, M ;
Slatkin, DN ;
Thomlinson, WC ;
Yamamoto, K ;
Zhong, Z .
PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (02) :371-387
[9]   Instrumentation of the ESRF medical imaging facility [J].
Elleaume, H ;
Charvet, AM ;
Berkvens, P ;
Berruyer, G ;
Brochard, T ;
Dabin, Y ;
Dominguez, MC ;
Draperi, A ;
Fiedler, S ;
Goujon, G ;
Le Duc, G ;
Mattenet, M ;
Nemoz, C ;
Perez, M ;
Renier, M ;
Schulze, C ;
Spanne, P ;
Suortti, P ;
Thomlinson, W ;
Esteve, F ;
Bertrand, B ;
Le Bas, JF .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 1999, 428 (2-3) :513-527
[10]  
Guinier A., 1963, XRAY DIFFRACTION CRY