A highly enantioselective, Pd-TangPhos-catalyzed hydrogenation of N-tosylimines

被引：160

作者：

Yang, Qin

Shang, Gao

Gao, Wenzhong

Deng, Jingen

Zhang, Xumu

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

[2] Chinese Acad Sci, Union Lab Asymmetr Synth, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Dept Chem, Beijing 100864, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 23期

关键词：

asymmetric catalysis; enantioselectivity; hydrogenation; imines; palladium;

D O I：

10.1002/anie.200600263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A catalyst system composed of Pd-(OCOCF 3)2 complexed with the electron-donating, rigid chiral diphosphane Tang-Phos gives excellent enantioselectivities (up to 99% ee) and conversions (up to > 99%) in the hydrogenation of N-tosylimines 1 (see scheme). A variety of aromatic, aliphatic, and cyclic chiral amines 2 can be prepared by this methodology. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3832 / 3835

页数：4

共 62 条

[1] Pd-catalyzed asymmetric hydrogenation of α-fluorinated iminoesters in fluorinated alcohol:: A new and catalytic enantioselective synthesis of fluoro α-amino acid derivatives [J].