Asymmetric Michael reaction promoted by new chiral phase-transfer catalysts

被引：32

作者：

Arai, S ^{[1
]}

Tokumaru, K ^{[1
]}

Aoyama, T ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 05期

关键词：

asymmetric synthesis; chiral ammonium salt; phase-transfer catalysis; Michael reaction;

D O I：

10.1248/cpb.52.646

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A catalytic asymmetric Michael reaction promoted by new chiral quaternary ammonium salts is described. The products are obtained with moderate ee (up to 75% ee), and the enantioselectivity is strongly dependent on both the substituents on the aromatic rings and the ammonium moiety in the catalysts.

引用

页码：646 / 648

页数：3

共 19 条

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