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Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker

被引：317
作者：
Hylton, Nola [1 ]
机构：
[1] Univ Calif San Francisco, San Francisco, CA 94143 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2006年 / 24卷 / 20期
关键词：
D O I：
10.1200/JCO.2006.06.8080
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is being used in oncology as a noninvasive method for measuring properties of the tumor microvasculature. There is potential for DCE-MRI to be used as an imaging biomarker to measure antiangiogenic effects of cancer treatments. This article reviews the general methodology for performing DCE-MRI and discusses existing data and challenges to applying DCE-MRI for treatment response assessment in clinical trials.
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页码：3293 / 3298
页数：6
相关论文
共 36 条
  • [21] Dynamic-enhanced MRI predicts metastatic potential of invasive ductal breast cancer
    Nagashima T.
    Suzuki M.
    Yagata H.
    Hashimoto H.
    Shishikura T.
    Imanaka N.
    Ueda T.
    Miyazaki M.
    [J]. Breast Cancer, 2002, 9 (3) : 226 - 230
  • [22] A phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points
    O'Donnell, A
    Padhani, A
    Hayes, C
    Kakkar, AJ
    Leach, M
    Trigo, JM
    Scurr, M
    Raynaud, F
    Phillips, S
    Aherne, W
    Hardcastle, A
    Workman, P
    Hannah, A
    Judson, I
    [J]. BRITISH JOURNAL OF CANCER, 2005, 93 (08) : 876 - 883
  • [23] Pharmacokinetic analysis of ductal carcinoma in situ of the breast using dynamic MR mammography
    Oshida, K
    Nagashima, T
    Ueda, T
    Yagata, H
    Tanabe, N
    Nakano, S
    Nikaidou, T
    Funatsu, H
    Hashimoto, H
    Miyazaki, M
    [J]. EUROPEAN RADIOLOGY, 2005, 15 (07) : 1353 - 1360
  • [24] Dynamic contrast enhanced MRI of prostate cancer: Correlation with morphology and tumour stage, histological grade and PSA
    Padhani, AR
    Gapinski, CJ
    Macvicar, DA
    Parker, GJ
    Suckling, J
    Revell, PB
    Leach, MO
    Dearnaley, DP
    Husband, JE
    [J]. CLINICAL RADIOLOGY, 2000, 55 (02) : 99 - 109
  • [25] Antivascular cancer treatments: functional assessments by dynamic contrast-enhanced magnetic resonance imaging
    Padhani, AR
    Leach, MO
    [J]. ABDOMINAL IMAGING, 2005, 30 (03): : 324 - 341
  • [26] Molecular imaging of antiangiogenic agents
    Rehman, S
    Jayson, GC
    [J]. ONCOLOGIST, 2005, 10 (02) : 92 - 103
  • [27] Can pre-operative contrast-enhanced dynamic MR imaging for prostate cancer predict microvessel density in prostatectomy specimens?
    Schlemmer, HP
    Merkle, J
    Grobholz, R
    Jaeger, T
    Michel, MS
    Werner, A
    Rabe, J
    van Kaick, G
    [J]. EUROPEAN RADIOLOGY, 2004, 14 (02) : 309 - 317
  • [28] Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer
    Su, MY
    Cheung, YC
    Fruehauf, JP
    Yu, H
    Nalcioglu, O
    Mechetner, E
    Kyshtoobayeva, A
    Chen, SC
    Hsueh, S
    McLaren, CE
    Wan, YL
    [J]. JOURNAL OF MAGNETIC RESONANCE IMAGING, 2003, 18 (04) : 467 - 477
  • [29] Tofts PS, 1999, J MAGN RESON IMAGING, V10, P223, DOI 10.1002/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO
  • [30] 2-S
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