Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker

被引:317
作者
Hylton, Nola [1 ]
机构
[1] Univ Calif San Francisco, San Francisco, CA 94143 USA
关键词
D O I
10.1200/JCO.2006.06.8080
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is being used in oncology as a noninvasive method for measuring properties of the tumor microvasculature. There is potential for DCE-MRI to be used as an imaging biomarker to measure antiangiogenic effects of cancer treatments. This article reviews the general methodology for performing DCE-MRI and discusses existing data and challenges to applying DCE-MRI for treatment response assessment in clinical trials.
引用
收藏
页码:3293 / 3298
页数:6
相关论文
共 36 条
  • [31] Dynamic contrast enhanced MRI in the differential diagnosis of soft tissue tumors
    Tuncbilek, N
    Karakas, HM
    Okten, OO
    [J]. EUROPEAN JOURNAL OF RADIOLOGY, 2005, 53 (03) : 500 - 505
  • [32] Dynamic MRI in indirect estimation of microvessel density, histologic grade, and prognosis in colorectal adenocarcinomas
    Tuncbilek, N
    Karakas, HM
    Altaner, S
    [J]. ABDOMINAL IMAGING, 2004, 29 (02): : 166 - 172
  • [33] Tuncbilek Nermin, 2003, Breast J, V9, P403, DOI 10.1046/j.1524-4741.2003.09508.x
  • [34] Correlative study of angiogenesis and dynamic contrast-enhanced magnetic resonance imaging features of hepatocellular carcinoma
    Wang, B
    Gao, ZQ
    Yan, X
    [J]. ACTA RADIOLOGICA, 2005, 46 (04) : 353 - 358
  • [35] Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
    Wedam, SB
    Low, JA
    Yang, SX
    Chow, CK
    Choyke, P
    Danforth, D
    Hewitt, SM
    Berman, A
    Steinberg, SM
    Liewehr, DJ
    Plehn, J
    Doshi, A
    Thomasson, D
    McCarthy, N
    Koeppen, H
    Sherman, M
    Zujewski, J
    Camphausen, K
    Chen, H
    Swain, SM
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (05) : 769 - 777
  • [36] Angiogenesis as a predictor of clinical outcome in cancer patients
    Weidner, N
    [J]. HUMAN PATHOLOGY, 2000, 31 (04) : 403 - 405