Effects of aging on B cell function

被引：100

作者：

Frasca, Daniela ^{[1
]}

Blomberg, Bonnie B. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33101 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 04期

关键词：

INDUCED CYTIDINE DEAMINASE; AGED MICE DIFFER; IG CLASS SWITCH; REPERTOIRE DIVERSITY; BACTERIAL-ANTIGENS; ANTIBODY-RESPONSE; GERMINAL-CENTERS; V-H; PHOSPHORYLCHOLINE-ANTIBODY; GENE HYPERMUTATION;

D O I：

10.1016/j.coi.2009.06.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 transcription factor. Effects on somatic hypermutation (SHM) have been varied depending on the system studied. Increase of AID in mice has shown improved CSR but not SHM. The reported microarray analysis of human B cell subsets may now be used to delineate B cell defects with aging and all the advances presented should lead to selecting agents for improved immune response in the elderly.

引用

页码：425 / 430

页数：6

共 57 条

[31] The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors [J].

Miller, JP ;

Allman, D .

JOURNAL OF IMMUNOLOGY, 2003, 171 (05) :2326-2330

[32] B cells and aging: Balancing the homeostatic equation [J].

Miller, Juli P. ;

Cancro, Michael P. .

EXPERIMENTAL GERONTOLOGY, 2007, 42 (05) :396-399

[33] Effects of aging on the common lymphoid progenitor to pro-B cell transition [J].

Min, HY ;

Montecino-Rodriguez, E ;

Dorshkind, K .

JOURNAL OF IMMUNOLOGY, 2006, 176 (02) :1007-1012

[34]

Muramatsu Masamichi, 2007, Adv Immunol, V94, P1, DOI 10.1016/S0065-2776(06)94001-2

[35]

NICOLETTI C, 1993, J IMMUNOL, V150, P543

[36]

NICOLETTI C, 1991, J IMMUNOL, V147, P2750

[37] Antibody diversity: one enzyme to rule them all [J].

Nussenzweig, MC ;

Alt, FW .

NATURE MEDICINE, 2004, 10 (12) :1304-1305

[38]

PAGANELLI R, 1992, CLIN EXP IMMUNOL, V90, P351

[39]

Pawelec G, 2002, FRONT BIOSCI-LANDMRK, V7, pD1056

[40] E protein function in lymphocyte development [J].

Quong, MW ;

Romanow, WJ ;

Murre, C .

ANNUAL REVIEW OF IMMUNOLOGY, 2002, 20 :301-322

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