CEACAM1: contact-dependent control of immunity

被引：409

作者：

Gray-Owen, Scott D. ^{[1
]}

Blumberg, Richard S.

机构：

[1] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Gastroenterol Div, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 06期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

D O I：

10.1038/nri1864

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. Recent studies show that there is an important role for members of the CEACAM family in modulating the immune responses associated with infection, inflammation and cancer. In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types.

引用

页码：433 / 446

页数：14

共 134 条

[1] CEACAM1 modulates epidermal growth factor receptor-mediated cell proliferation [J].

Abou-Rjaily, GA ;

Lee, SJ ;

May, D ;

Al-Share, QY ;

DeAngelis, AM ;

Ruch, RJ ;

Neumaier, M ;

Kalthoff, H ;

Lin, SH ;

Najjar, SM .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (07) :944-952

[2] Timeline - Jurkat T cells and development of the T-cell receptor signalling paradigm [J].

Abraham, RT ;

Weiss, A .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (04) :301-308

[3] DEVELOPMENT OF A RADIOIMMUNOASSAY FOR PREGNANCY-ASSOCIATED PLASMA PROTEIN-A AND ESTABLISHMENT OF NORMAL LEVELS IN THE 1ST TRIMESTER OF PREGNANCY [J].

ANTHONY, F ;

MASSON, GM ;

WOOD, PJ .

ANNALS OF CLINICAL BIOCHEMISTRY, 1983, 20 (JAN) :26-30

[4]

Bamberger AM, 1998, AM J PATHOL, V152, P1401

[5]

Beauchemin N, 1999, EXP CELL RES, V252, P243

[6] Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells [J].

Beauchemin, N ;

Kunath, T ;

Robitaille, J ;

Chow, B ;

Turbide, C ;

Daniels, E ;

Veillette, A .

ONCOGENE, 1997, 14 (07) :783-790

[7] CARCINOEMBRYONIC ANTIGEN, A HUMAN-TUMOR MARKER, FUNCTIONS AS AN INTERCELLULAR-ADHESION MOLECULE [J].

BENCHIMOL, S ;

FUKS, A ;

JOTHY, S ;

BEAUCHEMIN, N ;

SHIROTA, K ;

STANNERS, CP .

CELL, 1989, 57 (02) :327-334

[8] Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC) [J].

Berger, CN ;

Billker, O ;

Meyer, TF ;

Servin, AL ;

Kansau, I .

MOLECULAR MICROBIOLOGY, 2004, 52 (04) :963-983

[9] Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways [J].

Billker, O ;

Popp, A ;

Brinkmann, V ;

Wenig, G ;

Schneider, J ;

Caron, E ;

Meyer, TF .

EMBO JOURNAL, 2002, 21 (04) :560-571

[10] Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae [J].

Booth, JW ;

Telio, D ;

Liao, EH ;

McCaw, SE ;

Matsuo, T ;

Grinstein, S ;

Gray-Owen, SD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (16) :14037-14045

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