Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis

被引：138

作者：

Spellberg, BJ

Ibrahim, AS

Avanesian, V

Fu, Y

Myers, C

Phan, QT

Filler, SG

Yeaman, MR

Edwards, JE

机构：

[1] Harbor UCLA Med Ctr, Med Ctr, Los Angeles Biomed Res Inst, Div Infect Dis,Dept Med, Torrance, CA 90502 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 02期

关键词：

D O I：

10.1086/504691

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have shown that vaccination with the recombinant N terminus of Als1p (rAls1p-N) protects mice against disseminated and oropharyngeal candidiasis. We now report that vaccination of mice with a related candidate, rA1s3p-N, induces a broader antibody response than rA1s1p-N and a similar cell-mediated immune response. The rA1s3p-N vaccine was equally as effective as rA1s1p-N against disseminated candidiasis but was more effective than rAls1p-N against oropharyngeal or vaginal candidiasis. Antibody titers did not correlate with protection against disseminated candidiasis, but delayed-type hypersensitivity did. The rA1s3p-N vaccine is a promising new vaccine candidate for further exploration to prevent systemic and mucosal candidal infections.

引用

页码：256 / 260

页数：5

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