TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

被引：138

作者：

Winter, E ^{[1
]}

Ponting, CR ^{[1
]}

机构：

[1] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(02)02154-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.

引用

页码：381 / 383

页数：3

共 21 条

[1] MOTOR-NEURON DEGENERATION OF MICE IS A MODEL OF NEURONAL CEROID LIPOFUSCINOSIS (BATTENS DISEASE) [J].

BRONSON, RT ;

LAKE, BD ;

COOK, S ;

TAYLOR, S ;

DAVISSON, MT .

ANNALS OF NEUROLOGY, 1993, 33 (04) :381-385

[2]

DMELLO NP, 1994, J BIOL CHEM, V269, P15451

[3]

FAUST JR, 1994, J BIOL CHEM, V269, P10150

[4] CHROMA: consensus-based colouring of multiple alignments for publication [J].

Goodstadt, L ;

Ponting, CP .

BIOINFORMATICS, 2001, 17 (09) :845-846

[5] C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p [J].

Guillas, I ;

Kirchman, PA ;

Chuard, R ;

Pfefferli, M ;

Jiang, JC ;

Jazwinski, SM ;

Conzelmann, A .

EMBO JOURNAL, 2001, 20 (11) :2655-2665

[6] TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum [J].

Hegde, RS ;

Voigt, S ;

Rapoport, TA ;

Lingappa, VR .

CELL, 1998, 92 (05) :621-631

[7] A comprehensive two-hybrid analysis to explore the yeast protein interactome [J].

Ito, T ;

Chiba, T ;

Ozawa, R ;

Yoshida, M ;

Hattori, M ;

Sakaki, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4569-4574

[8] Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human [J].

Jiang, JC ;

Kirchman, PA ;

Zagulski, M ;

Hunt, J ;

Jazwinski, SM .

GENOME RESEARCH, 1998, 8 (12) :1259-1272

[9] Cellular pathology and pathogenic aspects of neuronal ceroid lipofuscinoses [J].

Kida, E ;

Golabek, AA ;

Wisniewski, KE .

BATTEN DISEASE: DIAGNOSIS, TREATMENT, AND RESEARCH, 2001, 45 :35-68

[10] The sterol-sensing domain: multiple families, a unique role? [J].

Kuwabara, PE ;

Labouesse, M .

TRENDS IN GENETICS, 2002, 18 (04) :193-201

← 1 2 3 →