Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity

被引：18

作者：

Boehm, Jannic

Ehrlich, Ingrid

Hsieh, Helen

Malinow, Roberto

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA

来源：

LEARNING & MEMORY | 2006年 / 13卷 / 05期

关键词：

D O I：

10.1101/lm.253506

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-Iigand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced synaptic plasticity.

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收藏

页码：562 / 565

页数：4

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