Design of selective Cathepsin inhibitors

被引：28

作者：

Bethel, Paul A. ^{[1
]}

Gerhardt, Stefan ^{[1
]}

Jones, Emma V. ^{[1
]}

Kenny, Peter W. ^{[1
]}

Karoutchi, Galith I. ^{[1
]}

Morley, Andrew D. ^{[1
]}

Oldham, Keith ^{[1
]}

Rankine, Neil ^{[1
]}

Augustin, Martin ^{[2
]}

Krapp, Stephan ^{[2
]}

Simader, Hannes ^{[2
]}

Steinbacher, Stefan ^{[2
]}

机构：

[1] AstraZeneca, RIRA, Mereside, Macclesfield SK10 4TG, Cheshire, England

[2] Proteros Biostruct, D-82152 Martinsried, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 16期

关键词：

Cathepsin; Cathepsin B; Cathepsin K; Cathepsin L; Cathepsin L2; Cathepsin S; Cathepsin V; Cysteine protease; Nitrile; Covalent inhibitor; Selectity; Protein structure; X-ray crystallography; Structure-based design; Hydrogen bonding; Hot spot; Electrostatic; Hydrogen bond; HOT-SPOTS;

D O I：

10.1016/j.bmcl.2009.06.090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：4622 / 4625

页数：4

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