Initiated CVD of Poly(2-Hydroxyethyl Methacrylate) Hydrogels: Synthesis, Characterization and In-vitro Biocompatibility

被引：35

作者：

Bose, Ranjita K. ^{[1
]}

Lau, Kenneth K. S. ^{[1
]}

机构：

[1] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA

来源：

CHEMICAL VAPOR DEPOSITION | 2009年 / 15卷 / 4-6期

关键词：

cell adhesion; cytotoxicity; hydrogel; initiated CVD; PHEMA; CHEMICAL-VAPOR-DEPOSITION; 2-HYDROXYETHYL METHACRYLATE; CELL ADHESION; PLASMA; FILMS; ADSORPTION; ICVD; CYTOTOXICITY; ACRYLATES); ROUGHNESS;

D O I：

10.1002/cvde.200806748

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Initiated (i)CVD, an all-dry, one-step surface polymerization technique, was used to synthesize thin film hydrogels of poly (2-hydroxyethyl methacrylate) (PHEMA). Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies showed stoichiometric PHEMA films obtained by iCVD. Differential scanning calorimetry (DSC) revealed a high glass transition temperature, indicative of high molecular mass polymer. In-vitro cell studies using adult human dermal fibroblasts (HDF) demonstrated the nontoxic nature and good cell adhesion properties of iCVD PHEMA films.

引用

页码：150 / 155

页数：6

共 42 条

[11] Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values [J].

Ferreira, L ;

Vidal, MM ;

Gil, MH .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 194 (02) :169-180

[12] Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility [J].

Fournier, E ;

Passirani, C ;

Montero-Menei, CN ;

Benoit, JP .

BIOMATERIALS, 2003, 24 (19) :3311-3331

[13] 2ND-ORDER TRANSITION TEMPERATURES AND RELATED PROPERTIES OF POLYSTYRENE .1. INFLUENCE OF MOLECULAR WEIGHT [J].

FOX, TG ;

FLORY, PJ .

JOURNAL OF APPLIED PHYSICS, 1950, 21 (06) :581-591

[14] Surface photo-grafting of polyurethane with 2-hydroxyethyl acrylate for promotion of human endothelial cell adhesion and growth [J].

Guan, JJ ;

Gao, GY ;

Feng, LX ;

Sheng, JC .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2000, 11 (05) :523-536

[15] ADHESION OF ESCHERICHIA-COLI ON TO A SERIES OF POLY(METHACRYLATES) DIFFERING IN CHARGE AND HYDROPHOBICITY [J].

HARKES, G ;

FEIJEN, J ;

DANKERT, J .

BIOMATERIALS, 1991, 12 (09) :853-860

[16] Hydrogels for biomedical applications [J].

Hoffman, Allan S. .

ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 :18-23

[17]

HOMSY C A, 1970, Journal of Biomedical Materials Research, V4, P341, DOI 10.1002/jbm.820040306

[18] Poly(2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine [J].

Hsiue, GH ;

Guu, JA ;

Cheng, CC .

BIOMATERIALS, 2001, 22 (13) :1763-1769

[19] Cadmium removal from human plasma by Cibacron Blue F3GA and thionein incorporated into polymeric microspheres [J].

Ibrahim, EH ;

Denizli, A ;

Bektas, S ;

Genç, Ö ;

Piskin, E .

JOURNAL OF CHROMATOGRAPHY B, 1998, 720 (1-2) :217-224

[20] Initiated chemical vapor deposition (iCVD) of poly( alkyl acrylates): An experimental study [J].

Lau, KKS ;

Gleason, KK .

MACROMOLECULES, 2006, 39 (10) :3688-3694

← 1 2 3 4 5 →