Facile methods for preparation of thiazolopyridine and tetrahydrothiazolopyridine derivatives

被引：19

作者：

Haginoya, N ^{[1
]}

Komoriya, S ^{[1
]}

Osanai, K ^{[1
]}

Yoshino, T ^{[1
]}

Nagata, T ^{[1
]}

Nagamochi, M ^{[1
]}

Muto, R ^{[1
]}

Yamaguchi, M ^{[1
]}

Nagahara, T ^{[1
]}

Kanno, H ^{[1
]}

机构：

[1] Daiichi Pharmaceut Co Ltd, Med Chem Res Lab, Edogawa Ku, Tokyo 1348630, Japan

来源：

HETEROCYCLES | 2004年 / 63卷 / 07期

关键词：

D O I：

10.3987/COM-04-10071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The improved routes to prepare tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid lithium salts (2 and 3) were developed. Route A is consisted of the improved preparation of thiazolopyridine intermediates, and Route B is applicable for a large scale synthesis of tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid derivatives. The methods we developed may serve as facile means for preparing thiazolopyridine and tetrahydrothiazolopyridine derivatives.

引用

页码：1555 / 1561

页数：7

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