Genetics of signal transduction and the effect of maternal smoking on sex ratio of offspring

被引:7
作者
Bottini, N
Magrini, A
Cosmi, E
Gloria-Bottini, F
Saccucci, P
Di Iorio, R
Bergamaschi, A
Bottini, E
机构
[1] Univ Roma Tor Vergata, Dept Neurosci, I-00133 Rome, Italy
[2] Burnham Inst, La Jolla, CA 92037 USA
[3] Univ Roma Tor Vergata, Dept Biopathol & Imaging Diagnost, Rome, Italy
[4] Univ Sassari, Inst Obstet & Gynecol, Sardinia, Italy
[5] Univ Roma La Sapienza, Dept Obstet & Gynecol, Rome, Italy
关键词
D O I
10.1002/ajhb.20058
中图分类号
Q98 [人类学];
学科分类号
030303 ;
摘要
We investigated the possible effects of ACP1 on the relationship between maternal smoking and sex ratio of offspring. ACP1 is a highly polymorphic enzyme involved in signal transduction of growth factors, glucose metabolism, flavoenzyme activity, and T-cell activation. A sample of 357 consecutive newborns from the population of Rome and a sample of 362 consecutive newborns from the population of Penne were studied. In both populations, among female newborns from smoking mothers there was a higher proportion of the A phenotype (associated with the lowest enzymatic activity) and a lower proportion of carriers of the *C allele (associated with the highest enzymatic activity) compared to female infants from nonsmoking mothers. In newborns from smoking mothers there was a positive correlation between sex ratio and ACP1 activity. The data suggest intrauterine selection induced by smoke that is dependent on sex and the ACP1 genotype of the zygote. It has been shown that low ACP1 activity is associated with high activity of the flavoenzyme glutathione reductase, an enzyme that has an important role in the protection of cellular structures from oxidative damage. Thus, the A phenotype may have a protective effect against oxidative damage by cigarette smoking through an enhancement of glutathione reductase activity. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:588 / 592
页数:5
相关论文
共 19 条
[1]  
[Anonymous], 1981, Statistical Tables
[2]   STUDIES OF IN-VITRO EFFECTS OF OXIDIZED GLUTATHIONE AND ACETYLPHENYLHYDRAZINE ON ACID PHOSPHATASES OF HUMAN RED BLOOD CELL - EXPERIMENTAL MODEL FOR INVESTIGATION OF HEMOLYTIC DRUG ACTION AT MOLECULAR LEVEL [J].
BOTTINI, E ;
MODIANO, G ;
SANTOLAM.C ;
FILIPPI, G ;
BUSINCO, L .
CLINICA CHIMICA ACTA, 1971, 31 (01) :243-&
[3]   ACP1 AND HUMAN ADAPTABILITY .1. ASSOCIATION WITH COMMON DISEASES - A CASE-CONTROL STUDY [J].
BOTTINI, E ;
GLORIABOTTINI, F ;
BORGIANI, P .
HUMAN GENETICS, 1995, 96 (06) :629-637
[4]   The genetics of signal transduction and the effect of smoking on intrauterine growth [J].
Bottini, E ;
Gloria-Bottini, F ;
La Torre, M ;
Lucarini, N .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2001, 30 (02) :400-402
[5]  
Bottini N, 2002, ARCH IMMUNOL THER EX, V50, P95
[6]   Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP) [J].
Bottini, N ;
Stefanini, L ;
Williams, S ;
Alonso, A ;
Jascur, T ;
Abraham, RT ;
Couture, C ;
Mustelin, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :24220-24224
[7]   Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner [J].
Bottini, N ;
Melon, GF ;
Borgiani, P ;
Giorgini, A ;
Buzzetti, R ;
Pozzilli, P ;
Lucarelli, P ;
Gloria-Bottini, F .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2002, 51 (04) :419-422
[8]   Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase [J].
Bottini, N ;
Gloria-Bottini, F ;
Lucarini, N ;
Ronchetti, PG ;
Fontana, L .
DISEASE MARKERS, 2000, 16 (3-4) :163-166
[9]   Parental periconceptional smoking and male: female ratio of newborn infants [J].
Fukuda, M ;
Fukuda, K ;
Shimizu, T ;
Andersen, CY ;
Byskov, AG .
LANCET, 2002, 359 (9315) :1407-1408
[10]   Phosphotyrosine protein phosphatases and diabetic pregnancy: An association between low molecular weight acid phosphatase and degree of glycemic control [J].
GloriaBottini, F ;
Gerlini, G ;
Lucarini, N ;
Borgiani, P ;
Amante, A ;
LaTorre, M ;
Antonacci, E ;
Bottini, E .
EXPERIENTIA, 1996, 52 (04) :340-343