Calcium gradients and the Golgi

被引：45

作者：

Dolman, Nick J. ^{[1
]}

Tepikin, Alexei V. ^{[1
]}

机构：

[1] Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England

来源：

CELL CALCIUM | 2006年 / 40卷 / 5-6期

基金：

英国惠康基金;

关键词：

Golgi; mitochondria; calcium; pancreas;

D O I：

10.1016/j.ceca.2006.08.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Changes in intracellular free calcium regulate many intracellular processes. With respect to the secretory pathway and the Golgi apparatus, changes in calcium concentration occurring either in the adjacent cytosol or within the lumen of the Golgi act to regulate Golgi function. Conversely, the Golgi sequesters calcium to shape cytosolic calcium signals as well as initiate them by releasing calcium via inositol-1,4,5-triphosphate (IP3) receptors, located on Golgi membranes. Local calcium transients juxtaposed to the Golgi (arising from release by the Golgi or other organelles) can activate calcium dependent signalling molecules located on or around the Golgi. This review focuses on the reciprocal relationship between the cell biology of the Golgi apparatus and intracellular calcium homeostasis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：505 / 512

页数：8

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