The formation of sensorimotor circuits

被引:95
作者
Goulding, M [1 ]
Lanuza, G [1 ]
Sapir, T [1 ]
Narayan, S [1 ]
机构
[1] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA
关键词
D O I
10.1016/S0959-4388(02)00371-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent studies have identified some of the key molecular pathways that control the genesis of spinal sensorimotor circuits. Transcription factors play a central role in these events, regulating both the specification of neurons that constitute these sensorimotor pathways and the expression of downstream molecules that control the wiring up of these neurons into topologically interconnected neuronal networks.
引用
收藏
页码:508 / 515
页数:8
相关论文
共 40 条
[21]   Neural crest specification regulated by the helix-loop-helix repressor Id2 [J].
Martinsen, BJ ;
Bronner-Fraser, M .
SCIENCE, 1998, 281 (5379) :988-991
[22]  
Mears SC, 1997, J NEUROSCI, V17, P3128
[23]  
Milner LD, 1999, J NEUROSCI, V19, P3007
[24]   Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons [J].
Mizuguchi, R ;
Sugimori, M ;
Takebayashi, H ;
Kosako, H ;
Nagao, M ;
Yoshida, S ;
Nabeshima, Y ;
Shimamura, K ;
Nakafuku, M .
NEURON, 2001, 31 (05) :757-771
[25]   Evx1 is a postmitotic determinant of V0 interneuron identity in the spinal cord [J].
Moran-Rivard, L ;
Kagawa, T ;
Saueressig, H ;
Gross, MK ;
Burill, J ;
Goulding, M .
NEURON, 2001, 29 (02) :385-399
[26]   The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord [J].
Müller, T ;
Brohmann, H ;
Pierani, A ;
Heppenstall, PA ;
Lewin, GR ;
Jessell, TM ;
Birchmeier, C .
NEURON, 2002, 34 (04) :551-562
[27]   CONTROL OF CELL BEHAVIOR DURING VERTEBRATE DEVELOPMENT BY SLUG, A ZINC-FINGER GENE [J].
NIETO, MA ;
SARGENT, MG ;
WILKINSON, DG ;
COOKE, J .
SCIENCE, 1994, 264 (5160) :835-839
[28]   Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2 [J].
Novitch, BG ;
Chen, AI ;
Jessell, TM .
NEURON, 2001, 31 (05) :773-789
[29]   Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1 [J].
Pierani, A ;
Moran-Rivard, L ;
Sunshine, MJ ;
Littman, DR ;
Goulding, M ;
Jessell, TM .
NEURON, 2001, 29 (02) :367-384
[30]   Regulation of motor neuron pool sorting by differential expression of type II cadherins [J].
Price, SR ;
Garcia, NVD ;
Ranscht, B ;
Jessell, TM .
CELL, 2002, 109 (02) :205-216