Synthesis of tetradentate mixed bisphosphonates -: new hydroxypyridinonate ligands for metal chelation therapy

被引：27

作者：

Bailly, T ^{[1
]}

Burgada, R ^{[1
]}

Prangé, T ^{[1
]}

Lecouvey, M ^{[1
]}

机构：

[1] Univ Paris 13, CNRS, UMR 7033, UFR SMBH,Lab Chim Struct Biomol, F-93017 Bobigny, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(02)02442-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a general study for developing better drugs suitable for Fe, Al, Co or lanthanide chelation therapy experiments, new mixed bisphosphonate-hydroxy pyridonates were synthesized. We demonstrate that the method using amidation reaction and dealkylation by concentrated hydrochloric acid gives excellent results for amino bisphosphonic acid ligands having at least two carbons between the amino group and the methylene bisphosphonic acid group. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：189 / 192

页数：4

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