Chemistry and biology of resorcylic acid lactones

被引：212

作者：

Winssinger, Nicolas ^{[1
]}

Barluenga, Sofia ^{[1
]}

机构：

[1] Univ Louis Pasteur Strasbourg 1, Inst Sci & Ingn Supramol, Organ & Bioorgan Chem Lab, F-67000 Strasbourg, France

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 01期

关键词：

D O I：

10.1039/b610344h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.

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页码：22 / 36

页数：15

相关论文

共 59 条

[1] Halohydrin and oxime derivatives of radicicol: Synthesis and antitumor activities [J].

Agatsuma, T ;

Ogawa, H ;

Akasaka, K ;

Asai, A ;

Yamashita, Y ;

Mizukami, T ;

Akinaga, S ;

Saitoh, Y .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (11) :3445-3454

[2]

AGATSUMA T, 1993, CHEM PHARM BULL, V41, P373, DOI 10.1248/cpb.41.373

[3] Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C [J].

Barluenga, S ;

Moulin, E ;

Lopez, P ;

Winssinger, N .

CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (17) :4935-4952

[4] Modular asymmetric synthesis of pochonin C. [J].

Barluenga, S ;

Lopez, P ;

Moulin, E ;

Winssinger, N .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (26) :3467-3470

[5] Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold [J].

Barluenga, Sofia ;

Dakas, Pierre-Yves ;

Terandin, Yoan ;

Meijer, Laurent ;

Winssinger, Nicolas .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (24) :3951-3954

[6] A comparison of signaling activities induced by taxol and desoxyepothilone B [J].

Bergstralh, DT ;

Taxman, DJ ;

Chou, TC ;

Danishefsky, S ;

Ting, JPY .

JOURNAL OF CHEMOTHERAPY, 2004, 16 (06) :563-576

[7] Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation [J].

Camacho, R ;

Staruch, MJ ;

DaSilva, C ;

Koprak, S ;

Sewell, T ;

Salituro, G ;

Dumont, FJ .

IMMUNOPHARMACOLOGY, 1999, 44 (03) :255-265

[8] Increased mature interleukin-1β (IL-1β) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1β-converting enzyme processing [J].

Cheneval, D ;

Ramage, P ;

Kastelic, T ;

Szelestenyi, T ;

Niggli, H ;

Hemmig, R ;

Bachmann, M ;

MacKenzie, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (28) :17846-17851

[9] Malnutrition could Predict 3-month Functional Prognosis in Mild Stroke Patients: Findings from a Nationwide Stroke Registry [J].

Qin, Haiqiang ;

Wang, Anxin ;

Zuo, Yingting ;

Zhang, Yaqing ;

Yang, Bo ;

Wei, Na ;

Zhang, Jing .

CURRENT NEUROVASCULAR RESEARCH, 2021, 18 (05) :489-496

[10] EFFICIENT AND MILD LACTONIZATION METHOD FOR SYNTHESIS OF MACROLIDES [J].

COREY, EJ ;

NICOLAOU, KC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (17) :5614-5616

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