Paracetamol toxicity: epidemiology, prevention and costs to the health-care system

被引：81

作者：

Sheen, CL ^{[1
]}

Dillon, JF

Bateman, DN

Simpson, KJ

Macdonald, TM

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Clin Pharmacol, Med Monitoring Unit, Dundee DD1 9SY, Scotland

[2] Univ Dundee, Ninewells Hosp & Med Sch, Dept Gastroenterol, Dundee DD1 9SY, Scotland

[3] Royal Infirm, Scottish Poisons Informat Bur, Edinburgh, Midlothian, Scotland

[4] Royal Infirm, Scottish Liver Transplant Unit, Edinburgh, Midlothian, Scotland

来源：

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2002年 / 95卷 / 09期

关键词：

D O I：

10.1093/qjmed/95.9.609

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Paracetamol has been used as an analgesic and antipyretic for many years, with toxicity first noted in the 1960s. Since then the incidence of poisoning has increased, and paracetamol is now the most common drug in self-poisoning, with a high rate of morbidity and mortality. The use, abuse and ways of reducing paracetamol toxicity are reviewed, but in view of the potential for harm, serious consideration should be given to changing the legal status of paracetamol, possibly to a prescription-only medicine.

引用

页码：609 / 619

页数：11

共 162 条

[71]

Kjaersgaard-Andersen P, 1991, Nurs Times, V87, P52

[72] Morphine-sparing effect of acetaminophen in pediatric day-case surgery [J].