Dynamics and diversity in autophagy mechanisms: lessons from yeast

被引：1332

作者：

Nakatogawa, Hitoshi ^{[1
,2
]}

Suzuki, Kuninori ^{[1
]}

Kamada, Yoshiaki ^{[3
]}

Ohsumi, Yoshinori ^{[1
]}

机构：

[1] Tokyo Inst Technol, Integrated Res Inst, Yokohama, Kanagawa 2268503, Japan

[2] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[3] Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 07期

关键词：

VACUOLE TARGETING PATHWAY; IN-VITRO RECONSTITUTION; PHOSPHATIDYLINOSITOL; 3-PHOSPHATE; MEMBRANE RECRUITMENT; CONJUGATION SYSTEM; SORTING MECHANISM; VESICLE FORMATION; STRUCTURAL BASIS; PICHIA-PASTORIS; PROTEIN;

D O I：

10.1038/nrm2708

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to humans. The most remarkable feature of autophagy is the synthesis of double membrane-bound compartments that sequester materials to be degraded in lytic compartments, a process that seems to be mechanistically distinct from conventional membrane traffic. The discovery of autophagy in yeast and the genetic tractability of this organism have allowed us to identify genes that are responsible for this process, which has led to the explosive growth of this research field seen today. Analyses of autophagy-related (Atg) proteins have unveiled dynamic and diverse aspects of mechanisms that underlie membrane formation during autophagy.

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收藏

页码：458 / 467

页数：10

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