Dynamics and diversity in autophagy mechanisms: lessons from yeast

被引：1332

作者：

Nakatogawa, Hitoshi ^{[1
,2
]}

Suzuki, Kuninori ^{[1
]}

Kamada, Yoshiaki ^{[3
]}

Ohsumi, Yoshinori ^{[1
]}

机构：

[1] Tokyo Inst Technol, Integrated Res Inst, Yokohama, Kanagawa 2268503, Japan

[2] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[3] Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 07期

关键词：

VACUOLE TARGETING PATHWAY; IN-VITRO RECONSTITUTION; PHOSPHATIDYLINOSITOL; 3-PHOSPHATE; MEMBRANE RECRUITMENT; CONJUGATION SYSTEM; SORTING MECHANISM; VESICLE FORMATION; STRUCTURAL BASIS; PICHIA-PASTORIS; PROTEIN;

D O I：

10.1038/nrm2708

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to humans. The most remarkable feature of autophagy is the synthesis of double membrane-bound compartments that sequester materials to be degraded in lytic compartments, a process that seems to be mechanistically distinct from conventional membrane traffic. The discovery of autophagy in yeast and the genetic tractability of this organism have allowed us to identify genes that are responsible for this process, which has led to the explosive growth of this research field seen today. Analyses of autophagy-related (Atg) proteins have unveiled dynamic and diverse aspects of mechanisms that underlie membrane formation during autophagy.

引用

页码：458 / 467

页数：10

共 103 条

[41] Organization of the pre-autophagosomal structure responsible for autophagosome formation [J].

Kawamata, Tomoko ;

Kamada, Yoshiaki ;

Kabeya, Yukiko ;

Sekito, Takayuki ;

Ohsumi, Yoshinori .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (05) :2039-2050

[42] Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae [J].

Kihara, A ;

Noda, T ;

Ishihara, N ;

Ohsumi, Y .

JOURNAL OF CELL BIOLOGY, 2001, 152 (03) :519-530

[43] Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway [J].

Kim, J ;

Scott, SV ;

Oda, MN ;

Klionsky, DJ .

JOURNAL OF CELL BIOLOGY, 1997, 137 (03) :609-618

[44] Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole [J].

Kim, J ;

Kamada, Y ;

Stromhaug, PE ;

Guan, J ;

Hefner-Gravink, A ;

Baba, M ;

Scott, SV ;

Ohsumi, Y ;

Dunn, WA ;

Klionsky, DJ .

JOURNAL OF CELL BIOLOGY, 2001, 153 (02) :381-396

[45] Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex [J].

Kim, J ;

Huang, WP ;

Klionsky, DJ .

JOURNAL OF CELL BIOLOGY, 2001, 152 (01) :51-64

[46] The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway [J].

Kirisako, T ;

Ichimura, Y ;

Okada, H ;

Kabeya, Y ;

Mizushima, N ;

Yoshimori, T ;

Ohsumi, M ;

Takao, T ;

Noda, T ;

Ohsumi, Y .

JOURNAL OF CELL BIOLOGY, 2000, 151 (02) :263-275

[47] Formation process of autophagosome is traced with Apg8/Aut7p in yeast [J].

Kirisako, T ;

Baba, M ;

Ishihara, N ;

Miyazawa, K ;

Ohsumi, M ;

Yoshimori, T ;

Noda, T ;

Ohsumi, Y .

JOURNAL OF CELL BIOLOGY, 1999, 147 (02) :435-446

[48] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes [J].

Klionsky, Daniel J. ;

Abeliovich, Hagai ;

Agostinis, Patrizia ;

Agrawal, Devendra K. ;

Aliev, Giumrakch ;

Askew, David S. ;

Baba, Misuzu ;

Baehrecke, Eric H. ;

Bahr, Ben A. ;

Ballabio, Andrea ;

Bamber, Bruce A. ;

Bassham, Diane C. ;

Bergamini, Ettore ;

Bi, Xiaoning ;

Biard-Piechaczyk, Martine ;

Blum, Janice S. ;

Breclesen, Dale E. ;

Brodsky, Jeffrey L. ;

Brumell, John H. ;

Brunk, Ulf T. ;

Bursch, Wilfried ;

Camougrand, Nadine ;

Cebollero, Eduardo ;

Cecconi, Francesco ;

Chen, Yingyu ;

Chin, Lih-Shen ;

Choi, Augustine ;

Chu, Charleen T. ;

Chung, Jongkyeong ;

Clarke, Peter G. H. ;

Clark, Robert S. B. ;

Clarke, Steven G. ;

Clave, Corinne ;

Cleveland, John L. ;

Codogno, Patrice ;

Colombo, Maria I. ;

Coto-Montes, Ana ;

Cregg, James M. ;

Cuervo, Ana Maria ;

Debnath, Jayanta ;

Demarchi, Francesca ;

Dennis, Patrick B. ;

Dennis, Phillip A. ;

Deretic, Vojo ;

Devenish, Rodney J. ;

Di Sano, Federica ;

Dice, J. Fred ;

DiFiglia, Marian ;

Dinesh-Kumar, Savithramma ;

Distelhorst, Clark W. .

AUTOPHAGY, 2008, 4 (02) :151-175

[49] Autophagy: from phenomenology to molecular understanding in less than a decade [J].

Klionsky, Daniel J. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (11) :931-937

[50] A unified nomenclature for yeast autophagy-related genes [J].

Klionsky, DJ ;

Cregg, JM ;

Dunn, WA ;

Emr, SD ;

Sakai, Y ;

Sandoval, IV ;

Sibirny, A ;

Subramani, S ;

Thumm, M ;

Veenhuis, M ;

Ohsumi, Y .

DEVELOPMENTAL CELL, 2003, 5 (04) :539-545

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