mRNA transport in dendrites: RNA granules, motors, and tracks

被引：122

作者：

Hirokawa, Nobutaka ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cell Biol & Anat, Tokyo 1130033, Japan

来源：

JOURNAL OF NEUROSCIENCE | 2006年 / 26卷 / 27期

关键词：

microfilament; tubulin; transport; granule; RNA trafficking; intracellular signaling; cytoskeleton;

D O I：

10.1523/JNEUROSCI.1821-06.2006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The targeting of mRNAs to neuronal dendrites is an important protein sorting mechanism. Recent studies have revealed that mRNAs are transported by molecular motors. The kinesin superfamily protein KIF5 transports mRNAs such as calcium/calmodulin-dependent kinase II alpha(CaMKII alpha) and Arc mRNAs along microtubules in large granules containing proteins involved in RNA transport, protein synthesis, RNA helicases, heterogeneous nuclear ribonucleoproteins ( hnRNPs), and RNA-associated proteins. This transport is fundamental to local protein synthesis and to the regulation of neuronal function.

引用

收藏

页码：7139 / 7142

页数：4

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