Nonpeptide Bradykinin antagonist analogs based on a model of a Sterling-Winthrop nonpeptide Bradykinin antagonist overlapped with cyclic hexapeptide Bradykinin antagonist peptides

被引：7

作者：

Dankwardt, SM

Ferla, S

Krstenansky, JL

Bhakta, S

Ostrelich, H

Jarnagin, K

机构：

[1] Roche Bioscience, Palo Alto

[2] Affymax Research Institute, Palo Alto, CA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(97)00328-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A proposed overlap between cyclic hexapeptide Bradykinin antagonists and nonpeptide Bradykinin antagonists is discussed. Structural variations on both the peptides and nonpeptides support the proposed overlap based on an increase or decrease in the biological activities of the antagonists. (C) 1997 Elsevier Science Ltd.

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收藏

页码：1921 / 1926

页数：6

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