Diversity in protein recognition by PTB domains

被引：106

作者：

Forman-Kay, JD

Pawson, T

机构：

[1] Hosp Sick Children, Res Inst, Struct Biol & Biochem Program, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[3] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada

[4] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(99)00031-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphotyrosine-binding (PTB) domains were originally identified as modular domains that recognize phosphorylated Asn-Pro-Xxx-pTyr-containing proteins. Recent binding and structural studies of PTB domain complexes with target peptides have revealed a number of deviations from the previously described mode of interaction, with respect to both the sequences of possible targets and their structures within the complexes. This diversity of recognition by PTB domains extends and strengthens our general understanding of modular binding domain recognition.

引用

页码：690 / 695

页数：6

共 54 条

[1] SARFing the PDB
Alexandrov, NN
[J]. PROTEIN ENGINEERING, 1996, 9 (09): : 727 - 732
[2] Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
Baraldi, E
Carugo, KD
Hyvönen, M
Lo Surdo, P
Riley, AM
Potter, BVL
O'Brien, R
Ladbury, JE
Saraste, M
[J]. STRUCTURE, 1999, 7 (04) : 449 - 460
[3] BLAIKIE P, 1994, J BIOL CHEM, V269, P32031
[4] Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: Implications for Cbl's function and oncogenicity
Bonita, DP
Miyake, S
Lupher, ML
Langdon, WY
Band, H
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (08) : 4597 - 4610
[5] Borg JP, 1996, MOL CELL BIOL, V16, P6229
[6] EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family
Callebaut, I
Cossart, P
Dehoux, P
[J]. FEBS LETTERS, 1998, 441 (02): : 181 - 185
[7] Numb-associated kinase interacts with the phosphotyrosine binding domain of numb and antagonizes the function of numb in vivo
Chien, CT
Wang, SW
Rothenberg, M
Jan, LY
Jan, YN
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (01) : 598 - 607
[8] The PTB domain expands both the PH-domain set and peptide-protein recognition motifs; The PDZ domain shows an intriguing resemblance.
Cowburn, D
[J]. STRUCTURE, 1996, 4 (09) : 1005 - 1008
[9] Peptide recognition by PTB and PDZ domains
Cowburn, D
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (06) : 835 - 838
[10] Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1
Dhe-Paganon, S
Ottinger, EA
Nolte, RT
Eck, MJ
Shoelson, SE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) : 8378 - 8383

← 1 2 3 4 5 6 →