Diversity in protein recognition by PTB domains

被引：106

作者：

Forman-Kay, JD

Pawson, T

机构：

[1] Hosp Sick Children, Res Inst, Struct Biol & Biochem Program, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[3] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada

[4] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(99)00031-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphotyrosine-binding (PTB) domains were originally identified as modular domains that recognize phosphorylated Asn-Pro-Xxx-pTyr-containing proteins. Recent binding and structural studies of PTB domain complexes with target peptides have revealed a number of deviations from the previously described mode of interaction, with respect to both the sequences of possible targets and their structures within the complexes. This diversity of recognition by PTB domains extends and strengthens our general understanding of modular binding domain recognition.

引用

页码：690 / 695

页数：6

共 54 条

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