Regulation of Thrombin Activity with a Bifunctional Aptamer and Hemin: Development of a New Anticoagulant and Antidote Pair

被引：32

作者：

Wang, Jing ^{[1
,2
]}

Cao, Ya ^{[1
,2
]}

Chen, Guifang ^{[1
,2
]}

Li, Genxi ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ, Dept Biochem, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Natl Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[3] Shanghai Univ, Lab Biosensing Technol, Sch Life Sci, Shanghai 200444, Peoples R China

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 13期

基金：

中国国家自然科学基金;

关键词：

anticoagulants; aptamers; DNA structures; G-quadruplexes; hemin; ligand design; PEROXIDASE-ACTIVITY; BINDING-KINETICS; DNA; COMPLEX; TRANSFUSION; METASTASIS; MOLECULES; DNAZYME; LIGANDS; CANCER;

D O I：

10.1002/cbic.200900408

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：2171 / 2176

页数：6

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