The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC

被引：228

作者：

Nagakubo, S

Nishino, K

Hirata, T

Yamaguchi, A

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Ibaraki, Osaka 5670047, Japan

[2] CREST, Japan Sci & Technol Corp, Osaka 5670047, Japan

[3] Osaka Univ, Fac Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 15期

关键词：

D O I：

10.1128/JB.184.15.4161-4167.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Overproduction of the response regulator BaeR confers resistance to novobiocin and bile salts in a DeltaacrAB mutant by stimulating drug exporter gene expression. The mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system, are responsible for resistance. The MdtABC system comprises the transmembrane MdtB/MdtC heteromultimer and MdtA membrane fusion protein. MdtAC also confers bile salt, but not novobiocin, resistance. This indicates that the evolution from an MdtC homomultimer to an MdtBC heteromultimer contributed to extend the drug resistance spectrum. A BLAST search suggested that such a heteromultimer-type RND exporter constitutes a unique family among gram-negative organisms.

引用

页码：4161 / 4167

页数：7

共 26 条

[1] The BaeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate [J].