The σ factors of Mycobacterium tuberculosis

被引：174

作者：

Rodrigue, Sebastien

Provvedi, Roberta

Jacques, Pierre-Etienne

Gaudreau, Luc

Manganelli, Riccardo

机构：

[1] Univ Padua, Dipartimento Istol Microbiol & Biotecnol Med, I-35121 Padua, Italy

[2] Univ Padua, Dipartimento Biol, I-35121 Padua, Italy

[3] Univ Sherbrooke, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

来源：

FEMS MICROBIOLOGY REVIEWS | 2006年 / 30卷 / 06期

关键词：

mycobacteria; tuberculosis; sigma factor; posttranslational regulation; stress response; virulence;

D O I：

10.1111/j.1574-6976.2006.00040.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium tuberculosis is a remarkable pathogen capable of adapting and surviving in various harsh conditions. Correct gene expression regulation is essential for the success of this process. The reversible association of different sigma factors is a common mechanism for reprogramming bacterial RNA polymerase and modulating the transcription of numerous genes. Thirteen putative sigma factors are encoded in the M. tuberculosis genome, several being important for virulence. Here, we analyse the latest information available on mycobacterial sigma factors and discuss their roles in the physiology and virulence of M. tuberculosis.

引用

页码：926 / 941

页数：16

共 107 条

[1] Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice [J].