Nanoparticles for cellular drug delivery: Mechanisms and factors influencing delivery

被引:137
作者
Chavanpatil, Mahesh D.
Khdair, Ayman
Panyam, Jayanth [1 ]
机构
[1] Wayne State Univ, Dept Pharmaceut Sci, Eugene Applebaum Coll Pharm & Hlth Sci, Detroit, MI 48201 USA
[2] Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48201 USA
关键词
gene delivery; endocytosis; receptors; ligands; antibodies; trafficking;
D O I
10.1166/jnn.2006.443
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Polymeric nanoparticles have demonstrated enormous potential as cellular drug delivery vehicles. Nanoparticles improve drug's stability as well as its availability and retention at the target intracellular site of action. Therapeutic efficacy of nanoparticles can be further enhanced by conjugating specific ligands to nanoparticle surface. Ligand conjugation can also be used to favorably modify the intracellular disposition of nanoparticles. A number of ligands are available for this purpose; use of a specific ligand depends on the target cell, the material used for nanoparticle formulation, and the chemistry available for ligand-nanoparticle conjugation. Cellular drug delivery using nanoparticles is also affected by clearance through the reticuloendothelial system. In this paper, we review the recent progress on our understanding of physicochemical factors that affect the cellular uptake of nanoparticles and the different cellular processes that could be exploited to enhance nanoparticle uptake into cells.
引用
收藏
页码:2651 / 2663
页数:13
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