Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer

被引：196

作者：

Sgarra, R

Rustighi, A

Tessari, MA

Di Bernardo, J

Altamura, S

Fusco, A

Manfioletti, G

Giancotti, V

机构：

[1] Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy

[2] Univ Udine, Dipartimento Patol & Med Sperimentale & Clin, I-33100 Udine, Italy

[3] Univ Naples Federico II, CNR, Ctr Endocrinol & Oncol Sperimentale, Dipartimento Biol & Patol Cellulare & Mol, I-80131 Naples, Italy

来源：

FEBS LETTERS | 2004年 / 574卷 / 1-3期

关键词：

high mobility group A proteins; methylation; phosphorylation; post-translational modification; chromatin; epigenetic process; cancer;

D O I：

10.1016/j.febslet.2004.08.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their post-translational modifications, such as phosphorylation, acetylation and methylation, are discussed and suggested as suitable targets for cancer chemotherapy. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

共 85 条

[51] ON THE PRESENCE OF 2 NEW HIGH MOBILITY GROUP-LIKE PROTEINS IN HELA S3 CELLS
LUND, T
HOLTLUND, J
FREDRIKSEN, M
LALAND, SG
[J]. FEBS LETTERS, 1983, 152 (02) : 163 - 167
[52] CDNA CLONING OF THE HMGI-C PHOSPHOPROTEIN, A NUCLEAR-PROTEIN ASSOCIATED WITH NEOPLASTIC AND UNDIFFERENTIATED PHENOTYPES
MANFIOLETTI, G
GIANCOTTI, V
BANDIERA, A
BURATTI, E
SAUTIERE, P
CARY, P
CRANEROBINSON, C
COLES, B
GOODWIN, GH
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (24) : 6793 - 6797
[53] HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas
Masciullo, V
Baldassarre, G
Pentimalli, F
Berlingieri, MT
Boccia, A
Chiappetta, G
Palazzo, J
Manfioletti, G
Giancotti, V
Viglietto, G
Scambia, G
Fusco, A
[J]. CARCINOGENESIS, 2003, 24 (07) : 1191 - 1198
[54] RETRACTED: Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation (Retracted article. See vol. 38, 2018)
Melillo, RM
Pierantoni, GM
Scala, S
Batista, S
Fedele, M
Stella, A
De Biasio, MC
Chiappetta, G
Fidanza, V
Condorelli, G
Santoro, M
Croce, CM
Viglietto, G
Fusco, A
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (07) : 2485 - 2495
[55] Coordination of a transcriptional switch by HMGI(Y) acetylation
Munshi, N
Agalioti, T
Lomvardas, S
Merika, M
Chen, GY
Thanos, D
[J]. SCIENCE, 2001, 293 (5532) : 1133 - 1136
[56] NISSEN MS, 1991, J BIOL CHEM, V266, P19945
[57] Molecular dissection of the architectural transcription factor HMGA2
Noro, B
Licheri, B
Sgarra, R
Rustighi, A
Tessari, MA
Chau, KY
Ono, SJ
Giancotti, V
Manfioletti, G
[J]. BIOCHEMISTRY, 2003, 42 (15) : 4569 - 4577
[58] Distinct organization of DNA complexes of various HMGI/Y family proteins and their modulation upon mitotic phosphorylation
Piekielko, A
Drung, A
Rogalla, P
Schwanbeck, R
Heyduk, T
Gerharz, M
Bullerdiek, J
Wisniewski, JR
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (03) : 1984 - 1992
[59] Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor α gene
Reeves, R
Leonard, WJ
Nissen, MS
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (13) : 4666 - 4679
[60] Molecular biology of HMGA proteins: hubs of nuclear function
Reeves, R
[J]. GENE, 2001, 277 (1-2) : 63 - 81

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