Altered amino acid homeostasis in subjects affected by fibromyalgia

被引：25

作者：

Bazzichi, Laura ^{[1
]}

Palego, Lionella ^{[2
]}

Giannaccini, Gino ^{[2
]}

Rossi, Alessandra ^{[2
]}

De Feo, Francesca ^{[1
]}

Giacomelli, Camillo ^{[2
]}

Betti, Laura ^{[2
]}

Giusti, Laura ^{[2
]}

Mascia, Giovanni ^{[2
]}

Bombardieri, Stefano ^{[1
]}

Lucacchini, Antonio ^{[2
]}

机构：

[1] Univ Pisa, Dept Internal Med, Div Rheumatol, I-56126 Pisa, Italy

[2] Univ Pisa, Dept Psychiat Neurobiol Pharmacol & Biotechnol, I-56126 Pisa, Italy

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 10-11期

关键词：

Fibromyalgia; Fatigue; Branched amino acids; Essential amino acids; Tyrosine; Taurine; Muscle energy; PLACEBO-CONTROLLED TRIAL; S-ADENOSYLMETHIONINE; CEREBROSPINAL-FLUID; DOUBLE-BLIND; PLASMA-CONCENTRATIONS; PAIN; TYROSINE; TAURINE; PERFORMANCE; MECHANISMS;

D O I：

10.1016/j.clinbiochem.2009.02.025

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Objectives: To evaluate plasma amino acid (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters. Design and methods: 20 AAs were assessed in 34 FM patients and in 18 healthy volunteers by means of a modified version of the Waters picotag method. Results: Significant lower plasma taurine, alanine, tyrosine (Tyr), valine, methionine, phenylalanine and threonine concentrations, and the sum of essential AAs were observed in FM patients vs healthy controls (P < 0.05). Tyr CAA' ratio and the sum of AAs competing with tryptophan for brain uptake were significantly reduced in FM (P < 0.05). A significant correlation was found between FM clinical parameters and certain AAs. Conclusions: Our results Suggest probable defects of gut malabsorption of certain AAs in FM patients. Moreover, given the reduced Tyr CAA' ratio in FM patients, a possible impairment of the cathecolaminergic system in the FM syndrome may be suggested. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1064 / 1070

页数：7

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