Back to the future: the 'old-fashioned' way to new medications for neurodegeneration

被引：60

作者：

Lansbury, PT

机构：

[1] Harvard Ctr Neurodegenerat & Repair, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis,Dept Neurol, Cambridge, MA 02139 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 07期

关键词：

D O I：

10.1038/nrn1435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Despite the increasing prevalence of Alzheimer's disease, Parkinson's disease and less common neurodegenerative diseases-and despite the large amount of primary research that has been carried out into the causes and pathogenic features of these conditions-progress toward effective treatments has been remarkably slow. Why is this, and what can be done to accelerate it? There are a number of obstacles to effective drug discovery for neurodegeneration, but by considering these problems it is possible to identify lessons for the future.

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收藏

页码：S51 / S57

页数：7

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